Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix.
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چکیده
منابع مشابه
Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix
PDGF is a powerful mitogen initially identified within platelets, but also shown to be produced by a wide variety of cell types. PDGF is encoded on two separate genes. These give rise to three polypeptides, PDGF B and two forms of PDGF A (SA and LA), resulting from alternative splicing of the PDGF A gene primary transcript. We report that in CHO cells transfected with PDGF gene constructs and p...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
A deletion in the extracellular domain of the alpha platelet-derived growth factor (PDGF) receptor differentially impairs PDGF-AA and PDGF-BB binding affinities.
32D cells transfected with the human alpha platelet-derived growth factor receptor (alpha PDGFR) bind PDGF-AA, -AB, and -BB isoforms with high affinity, and the binding of each can be efficiently competed by all three isoforms. In an effort to develop better understanding of spatial relationships of binding sites for PDGF-AA and -BB, we constructed an alpha PDGFR mutant which deleted amino acid...
متن کاملExtracellular Matrix Alters PDGF Regulation of Fibroblast Integrins
Extracellular matrix (ECM) and growth factors are potent regulators of cell phenotype. These biological mediators of cellular responses are potentially interactive and as such could drive cells through progressive phenotypes to create new tissue as in morphogenesis and wound repair. In fact, ECM composition changes during tissue formation accompanied by alterations in cell growth and migration....
متن کاملExtracellular Matrix Alters PDGF Regulation of Fibroblast Integrins
Extracellular matrix (ECM) and growth factors are potent regulators of cell phenotype. These biological mediators of cellular responses are potentially interactive and as such could drive cells through progressive phenotypes to create new tissue as in morphogenesis and wound repair. In fact, ECM composition changes during tissue formation accompanied by alterations in cell growth and migration....
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1993
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.121.5.1153